In vitro susceptibility of Haemophilus influenzae and neisseria gonorrhoeae to Ro 13-9904 in comparison with other beta-lactam antibiotics.
نویسندگان
چکیده
Ro 13-9904 has high in vitro activity, as does cefotaxime, against 57 Haemophilus influenzae and 60 Neisseria gonorrhoeae strains, including 5 and 11 beta-lactamase-producing strains in each group, respectively.
منابع مشابه
Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin.
The in vitro activity of ceftriaxone (Ro 13-9904), a parenteral cephalosporin, was compared with that of other beta-lactam antibiotics. the compound was less active against Staphylococcus aureus and Staphylococcus epidermidis than was cephalothin or cefamandole, but it was comparable to cefoxitin, cefotaxime, and moxalactam in inhibiting most isolates of S. aureus at 3.1 microgram/ml. Ro 13-990...
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Ro 13-9904, a new parenteral cephalosporin, was found to have high in vitro activity against Enterobacteriaceae and other gram-negative bacteria, including various isolates resistant to cefuroxime, cefamandole, cefoxitin, and cefazolin. It showed promising activity against Pseudomonas aeruginosa. Although inhibitory against Staphylococcus aureus at concentrations readily achievable in plasma, i...
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متن کاملIn vitro activity of Ro 13-9904, a new beta-lactamase-stable cephalosporin.
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متن کاملRo 13-9904: affinity for penicillin binding proteins and effect on cell wall synthesis.
Studies on the binding of Ro 13-9904, a new broad-spectrum cephalosporin, showed that it had higher affinities for PBPs 1b, 2, and 3 of Escherichia coil (3> 1b>2) than cefazolin, cephaloridine, cephalothin or cephalexin. With Haemophilus inf uenzae, Ro 13-9904 showed highest affinities for PBPS4 and 5 followed by PBP 2. It inhibited total cell wall synthesis at lower concentrations than the oth...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1981